Phenylpropanoids and polyketides
Medchemexpress LLC Ozagrel hydrochloride | 78712-43-3 | 99.9% | 100 MG
Ozagrel hydrochloride | 78712-43-3 | 99.9% | 100 MG
Medchemexpress LLC 3,4-Dimethoxycinnamic acid | 2316-26-9 | 208.21 | 1 G
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. It exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway.
- Attenuates the ethanol-induced apoptosis of ethanol-exposed L-02 cells
- Inhibits the expression levels of Nox4 and p22phox in L-02 cells
- Attenuates ethanol-induced MAPK phosphorylation in L-02 cells
- Decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase
- Downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner
Medchemexpress LLC Ozagrel hydrochloride | 78712-43-3 | MFCD06795644 | >98.0% | 10 MG
Ozagrel hydrochloride is the hydrochloride salt of ozagrel, a selective thromboxane A2 (TXA2) synthase inhibitor used in preclinical research to study platelet aggregation, ischemic stroke, asthma, and thromboembolic disease.
- Selective thromboxane A2 (TXA2) synthase inhibitor with reported IC50 ~11 nM.
- Reduces thromboxane A2 production, leading to anti-platelet aggregation and vasodilation.
- Hydrochloride salt supplied as a powder suitable for in vitro and in vivo research.
- Typical molecular weight 264.71 g/mol and formula C13H13ClN2O2.
- High purity commonly reported as ≥98% (verify with vendor for specific lot).
- Store powder at -20°C for long-term stability; in solution, store at -80°C.
Sigma Aldrich Fine Chemicals Biosciences p-Coumaric acid primary reference standard | 501-98-4 | MFCD00004399 | 50MG
p-Coumaric acid primary reference standard | Mol Wt: 164.16 | 501-98-4 | MFCD00004399 | 50MG
Medchemexpress LLC Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) | 132465-11-3 | 99.41% | 321.33 | 50 MG
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent inhibitor of 12/15-Lipoxygenases (LO) with potential for type 1 diabetes mellitus research. In vitro studies demonstrated that CDC partially suppressed dextran transport, while in vivo, it antagonized the effect of high glucose on protein phosphorylation, mitigating endothelial cell barrier destruction in a mouse diabetes mellitus model.
- Potent 12/15-Lipoxygenases (LO) inhibitor
- Potential for research of type 1 diabetes mellitus
- Partially suppressed dextran transport increased by high glucose or 12(S)-HETE in vitro
- Antagonized the effect of high glucose on protein phosphorylation in vivo
- Mitigated endothelial cell barrier destruction in a mouse diabetes mellitus model
Medchemexpress LLC (-)-Epigallocatechin Gallate | 989-51-5 | 99.75% | 458.37 | 200 MG
(-)-Epigallocatechin Gallate | 989-51-5 | 99.75% | 458.37 | 200 MG
Medchemexpress LLC 3-Acetylcoumarin | 3949-36-8 | 97.0% | 188.18 | 1 ML
3-Acetylcoumarin (Compound 4) is a chemical compound demonstrating acaricidal activity against Tetranychus cinnabarinus. It also inhibits human recombinant MAO-B with an IC50 of 14.45 μM and exhibits cytotoxicity against human SH-SY5Y cells with an IC50 of 75 μM.
- Exhibits acaricidal activity against Tetranychus cinnabarinus
- Inhibits human recombinant MAO-B (IC50 of 14.45 μM)
- Demonstrates cytotoxicity against human SH-SY5Y cells (IC50 of 75 μM)
Medchemexpress LLC Tyrphostin AG1296 | 146535-11-7 | 99.7% | 266.29 | 25 MG
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. It inhibits signaling of human PDGF α- and β-receptors, as well as the related stem cell factor receptor (c-Kit). This compound is also a potent inhibitor of FLT3, with an IC50 in the micromolar range.
- Potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR)
- Inhibits signaling of human PDGF α- and β-receptors
- Inhibits signaling of the related stem cell factor receptor (c-Kit)
- Potent inhibitor of FLT3
- Suppresses viability of PLX4032-resistant melanoma cells
- Induces apoptosis of A375R cells
- Inhibits PDGFR phosphorylation
- Suppresses A375R tumor growth in vivo
- Inhibits atherosclerotic plaque progression
Medchemexpress LLC Daunorubicin hydrochloride | 23541-50-6 | 99.7% | 500 MG
Daunorubicin hydrochloride, also known as Daunomycin, is a potent topoisomerase II inhibitor with significant anti-tumor activity. This anthracycline antibiotic functions by inhibiting DNA and RNA synthesis, leading to the suppression of cancer cell viability. It is recognized for its ability to induce apoptosis and necrosis in target cells.
- Potent anti-tumor agent
- Inhibits DNA and RNA synthesis
- Induces apoptosis and necrosis
- Anthracycline antibiotic
- Useful in research for various cancers, including leukemia and lymphomas
![eMolecules 2-[3-(2-Benzimidazolyl)phenyl)]-5-methyl-4-phenylthiazole | 1414661-83-8 | MFCD22666467 | 5g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502142756.JPG-250.jpg)
eMolecules 2-[3-(2-Benzimidazolyl)phenyl)]-5-methyl-4-phenylthiazole | 1414661-83-8 | MFCD22666467 | 5g
Oakwood Chemicals | 2-[3-(2-Benzimidazolyl)phenyl)]-5-methyl-4-phenylthiazole | 5g | 480147800 | 098092 | | 1414661-83-8 | MFCD22666467 | 367.470 | C23H17N3S
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Medchemexpress LLC 7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester | 134471-24-2 | >=96.0% | 1 G
7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is the amine-reactive succinimidyl ester of 7-Hydroxycoumarin-3-carboxylic acid. It is a blue fluorescent dye used for labeling proteins and nucleic acids.
- Blue fluorescent dye
- Amine-reactive succinimidyl ester
- Used for labeling proteins and nucleic acids
TARGETMOL CHEMICALS INC NOBILETIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa). purity: 98%